Pathophysiology

The exact cause of schizophrenia is not fully understood, but it is believed to involve a complex interaction of genetic, environmental, and neurochemical factors. Brain imaging studies have shown structural and functional abnormalities in the brains of individuals with schizophrenia, particularly affecting areas involved in perception, emotion, and cognition.

Medical Diagnosis

Clinical Evaluation
Symptoms: Hallucinations (auditory, visual, or tactile), delusions (false beliefs), disorganized thinking (speech), grossly disorganized or abnormal motor behavior (e.g., catatonia), negative symptoms (reduced emotional expression or avolition).
Duration: Symptoms persist for at least 6 months, with significant impairment in social or occupational functioning.

Diagnostic Criteria
DSM-5 Criteria: Diagnosis based on specific symptoms and duration of symptoms, ruling out other possible medical or psychiatric conditions.

Signs and Symptoms

Hallucinations (perceiving things that are not present, often auditory).
Delusions (strongly held false beliefs not based on reality).
Disorganized thinking (e.g., fragmented or nonsensical speech).
Grossly disorganized or abnormal motor behavior (e.g., agitation, catatonia).
Negative symptoms (reduced emotional expression, lack of motivation or pleasure).
Cognitive deficits (e.g., problems with memory, attention, or executive function).

Treatment

Treatment for schizophrenia typically involves a combination of medication, psychotherapy, and support services:
Antipsychotic Medications: First-line treatment to manage symptoms and prevent relapse.
Psychotherapy: Cognitive behavioral therapy (CBT) or supportive therapy to help manage symptoms, improve coping skills, and enhance insight.
Social Support: Family therapy, vocational rehabilitation, and community support services to improve social functioning and quality of life.
Education and Counseling: Education about the illness, medication adherence, and coping strategies for individuals and their families.
Hospitalization: In severe cases or during acute episodes, hospitalization may be necessary for safety and stabilization.